Detection of the thrombophilic mutations in recurrent pregnancy loss
A.Oncescu, I.D. Suciu, C. Dragomir, A. VoichiĊ£oiu, A.M. Moraru, B. Marinescu
Rezumat: Almost 5% of women of fertile age can be affected by recurrent pregnancy and almost half of the cases are of unknown etiology. The Prothrombin G20210A gene polymorphism, Factor V Leiden mutation G1691A, MTHFR A1298C and C677T mutations, Fibrinogen G455A mutation, PAI-4G/5G are the most frequent thrombophilic mutations investigated. Determining their association is of really good interest because of the possible treatments which can increase the odds to have a live birth. The association with recurrent pregnancy loss is still controversial for many authors. We tested a group of 231 patients with recurrent pregnancy and 100 patients in a control group. The incidence of thrombophilic mutations was increased in the study group over the controls. The investigations for thrombophilia could be routinely introduced in the patients with recurrent pregnancy loss. Cuvinte cheie: thrombophilia, recurrent pregnancy loss, pregnancy.