The role of placental angiogenic factors determination in periodic evaluation of preeclampsia risk

M. Cirstoiu, D.C. Gunescu, O.M. Bodean, O. Munteanu, S. Vladareanu

Rezumat: Nationally, the methods used for diagnosis of pre-eclampsia have not significantly changed in the last 20 years. Diagnosis is based on monitoring maternal bllod pressure and confirming proteinuria. However, these signs are nonspecific and are generally present when preeclampsia manifests clinically. Determination of serum levels of angiogenic placental factors are especially that of the PIGF/sFIT-1 ratio (also known as index of angiogenesis) have an increased sensitivity and specificity in periodic assessment of the risk of preeclampsia, identifying the condition in early stages. Preeclampsia is a condition with severe consequences both maternal and fetal, and for that matter, a precocious diagnosis and an accurate evaluation of the severity of the disease are highly important in order to appoint an adequate treatment, thus decreasing the risk of complications.
Cuvinte cheie: preeclampsia, angiogenic placental factors, index of angiogenesis.