Hypercoagulability in pregnancy. Pathological and adaptive modifications.

M. Mitran, C. Georgescu, S. Vladareanu

Rezumat: The hemostasis of the maternal body differes from the one outside the pregnancy period. The hemostasis indicators highlight during pregnancy both the growth in thrombin production and fibrinolysis. Thrombopenia and the modifications of the plasmatic factors as well as the blood flow don’t trigger any alterations of the hemostasis during pregnancy but point out the presence of disease either associated to or induced by pregnancy. They can also lead to a worsening of these diseases. It is worth mentioning the presence of the clinical risk factors for a thrombotic accident (according to Wirchow’s clasical criteria) to which the biological factors are added as a consequence of the acquired or congenital thrombophilia. The thrombotic syndrome is considered to be the cause of a series of obstetrical accidents: repeated abortion, premature birth, intrauterine growth restriction, fetus decease in uterus, preeclamsia, the HELLP syndrome, DPPNI. The antithrombotic treatment, both clinically and biologically justified, not only prophylactic but also curative, can lead to an improvement of the obstetrical results.
Cuvinte cheie: pregnant, coagulation disorders, thrombosis, obstetrical risk, treatment.