Rezumat: Today reliability, rapidity and accuracy in clinical diagnostics are the first choices. Combination of molecular techniques and Bioinformatics have upgraded diagnostic methods and treating managements. Among advances clinical technologies, microarrays are effective diagnostics in medicine. Medical microbiology is consisted of medical bacteriology, medical mycology, and medical virology; clinical diagnostics of infectious and non-infectious diseases, gene expression profiling, genetic disorders, detection of pathogenic microbial agents and treatment are different pieces of medicine puzzles. The application of microarray in medicine are in progress. The most important problem for public use of microarrays is their expensive costs. Covering the costs of microarray technologies will change them into a gold standard method for diagnosis and treatment in public medical centers, laboratories and hospitals around the world. Cuvinte cheie: microarray, diagnosis, disease, medicine.