Correlation between vitamin D deficiency and fibrocystic mastopathy

B. Botezatu, R.G. Deaconescu

Rezumat: Fibrocystic dystrophy is one of the most frequent and common non-neoplastic pathologies whose symptomatology is represented by the appearance of painful nodules in the breast. Fibrocystic lesions have several etiological factors, the most important being considered the hormonal imbalance between estrogen and progesterone, manifested by excess estrogen that causes proliferations at the connective tissue level (fibrosis). The diagnosis of this pathology is based on symptoms and with the help of breast ultrasound, which can also be used in the puncture and drainage of large cysts. The treatment of fibrocystic breast disease is a medical one, by administering combined oral contraceptives, having a success rate of 70-90%. Breast ultrasound is an important technique for evaluating breast anatomy in benign and malignant pathologies. Fibrocystic mastopathy is most often associated with dense breasts with well-developed breast tissue. Epidemiological studies suggest that the level of vitamin D (25-hydroxycholecalciferol) below 20 ng/mL is associated with an increased risk of breast, colon and prostate cancer. In young people, vitamin D deficiency is associated with benign pathology (mammary cysts, fibroadenoma). This article presents a study in which 50 women, aged between 30 and 50 years old, were included, for a period of three years, all of them being diagnosed by ultrasound with fibrocystic mastopathy and all presenting vitamin D deficiency (below 20 ng/mL 25-hydroxyvitamin D) at the time of the examination.
Cuvinte cheie: vitamin D, fibrocystic mastopathy, breast ultrasound.