Risk factors for fetal cell-free DNA testing failure – literature review

S. Vasilescu, D. Meca, N. Ţurcan, M.M. Cîrstoiu

Rezumat: Noninvasive prenatal diagnosis, which has as the main purpose the detection of certain fetal genetic disorders, is possible due to the passage of fetal nucleated cells into maternal blood. It is important to know that there are studies that report important false-positive rates associated to these tests. We aimed to synthetize the main risk factors which may lead to the test failure through false-positive or false-negative results. Each of these factors should be taken into account when recommending noninvasive prenatal screening through fetal cell-free DNA analysis.
Cuvinte cheie: cell-free DNA, failure, prenatal testing.