Early sonographic signs in agenesis of the fetal corpus callosum

E. Nica, M. Mitran, B. Marinescu

Rezumat: Objectives. Although the agenesis of corpus callosum is currently a second-trimester diagnosis, it is a worthwhile pursuit to lower the gestational age at which this pathology should be at least suggested, if not diagnosed. Materials and method. We performed an ultrasound examination (2D and 3D) on women with a sigleton or twin pregnancy at 12 to 14 weeks of gestation. Images with measurements of midbrain and falx cerebri were acquired and their ratio computed, along with 3D volume with power Doppler images of the pericallosal arteries. We also performed a follow- up scan at 20-22 weeks of gestation in order to confirm the absence of the corpus callosum. Results. Nineteen fetuses with high suspicion on the first trimester were found with agenesis of corpus callosum at the second-trimester scan. Conclusions. Ultrasound measurements of midbrain/falx cerebri with calculated ratio and pericallosal artery in the first trimester could be a matter of concern for agenesis of corpus callosum.
Cuvinte cheie: first-trimester scan, agenesis of corpus callosum, midbrain, falx cerebri, ratio, pericallosal artery.