The challenge of thrombophilia: the profile of patients with rare compound thrombophilias

D. Voicu, O. Munteanu, L.V. Arsene, F. Păuleţ, O. Bodean, R. Eugen, M. Cîrstoiu

Rezumat: Thrombophilia is a multigenic disorder. Factor V Leiden mutation and protein gene G20210A mutation are the most common inherited thrombophilias. Individuals who are homozygous have a higher risk of thrombosis compared to those who are heterozygous. Inherited thrombophilia is associated with a predisposition to venous – not arterial – thromboembolism. Pregnancy increases the risk of developing venous thromboembolism. The aim of this study is to find the link between inherited thrombophilia (compound homozygous polymorphisms) and obstetric pathology in pregnant women.
Cuvinte cheie: venous thrombosis, thrombophilia, pregnancy, miscarriage.