A.A. Simionescu, C. Coşconel, C. Tătăruș, R. Scăunaşu, A. Filipescu
Rezumat: Oxytocin is the most common medication used to induce
or to accelerate labor and in the third-stage management
of labor. Since 2007, oxytocin has been classified as a
high-alert medication. It is well known that oxytocin exerts
a large range of central and peripheral effects, from the
modulation of neuroendocrine reflexes to the establishment
of complex social and bonding behaviors related to the
reproduction and care of the offspring. However, little has
been demonstrated about the intrapartum use of syntetic
oxytocin and the short-term and long-term effects on the
mother and foetus. The purpose of this article is to review
the main maternal and fetal side effects related to the
use of intrapartum oxytocin. In conclusion, oxytocin use
is associated with a decrease of the number of caesarean
delivery and with an increase of vaginal delivery. Although
it is the most common pharmacologic agent used during
labour, there is still a debate about the optimum dose
regimen use. Adverse maternal and neonatal outcomes
of oxytocin induction and augmentation of labour
are rare, but severe. The use of a clear protocol for the
administration and early recognition of side effects may
prevent adverse maternal and fetal complications. Cuvinte cheie: oxytocin, labor, side effects.