Predictive value of sFlt, PIGF versus sFlt/PIGF ratio test in patients at risk of preeclampsia

A.L. Moldoveanu, D. Oprescu, L. Novac

Rezumat: Hypertension is the most common medical problem encountered during pregnancy, complicating 2-3% of pregnancies. The cause of preeclampsia is not yet fully understood, but the disorder is thought to be due to placental malperfusion resulting from abnormal remodelling of maternal spiral arteries(1,2). Abnormal remodelling of maternal spiral arteries is observed in women with subsequent preeclampsia, leading to placental hypoperfusion and systemic endothelial dysfunction(3). Angiogenic factors are associated with the pathophysiology of preeclampsia. More evidence supports a role for angiogenic factors in the pathogenesis of preeclampsia, and sFlt-1 levels are strongly correlated with the severity of the syndrome(4).
Cuvinte cheie: preeclampsia, angiogenic factors, sFlt/PLGF ratio