Clinicopathological correlations in leiomyosarcoma of the uterine corpus – a short series of cases and literature review

O. Munteanu, D. Voicu, L. Arsene, A. Uzunov, M. Sajin, T.A. Georgescu, A. Dumitru, R. Albu, M.M. Cîrstoiu

Rezumat: Uterine sarcomas are a highly aggressive and morphologically heterogeneous group of tumors, with unpredictable clinical course and poor prognosis. According to the latest WHO classification of the tumors of the uterine corpus, uterine sarcomas are grouped into three main histological subtypes: leiomyosarcomas, endometrial stromal sarcomas and other entities. Uterine leiomyosarcoma is a rare type of cancer originating from the smooth muscle tissue of the uterine wall. It is estimated that leiomyosarcoma represents approximately 1% of all uterine malignancies, but it contributes to nearly 70% of all uterine sarcomas and to a significant proportion of uterine cancer deaths. Most uterine leiomyosarcomas occur in women over 40 years old, and their incidence increases rapidly after the age of 50. Due to their scarcity and lack of a pre-invasive stage of the disease, there is no consensus for the screening and early detection of these neoplasms.
Cuvinte cheie: uterine leiomyosarcoma, prognostic factors, stage, clinicopathological, IHC.