S.D. Popescu, A.M. Bănică, S. Vlădăreanu, R. Vlădăreanu
Rezumat: Aims. Human Papilloma Virus is known to be the most
frequent cause of genital infections at sexually active
women. The virus is transmitted mainly sexually but
epidemiological and clinical data suggest sufficient
evidence also for other routes of transmission. Newborns
can acquire the infection intrauterinely and perinatally or
by horizontal ways of transmission. We aimed to describe,
by reviewing the literature, the damaging effect of HPV
on pregnancy outcomes and the risk of the newborn to
develop recurrent respiratory papillomatosis. Also, we
assessed the risk of HPV bivalent and quadrivalent vaccine
in pregnancy and paediatric population. Method. We
carried out an electronic database search, such as Pubmed,
Medline, Google Scholar, for articles including “Human
Papilloma Virus”, “perinatal transmission”, “recurrent
respiratory papillomatosis”, “HPV vaccine”, “pregnancy
outcomes”. We selected articles published between 2015
and 2018. Conclusions. The main mode of transmission
from mother to newborn occurs during pregnancy and
at the time of delivery. The virus can also be transmitted
among the family members by close contact. There is
insufficient data to conclude about the impact of Human
Papilloma Virus on pregnancy and on the newborn,
so for a relevant understanding more research for a
long term and with an extended cohort is needed. Cuvinte cheie: Human Papilloma Virus, perinatal transmission, recurrent respiratory papillomatosis, HPV vaccine.