Maternal-fetal management and outcome in a case of uterine anatomic abnormality and obstetric antiphospholipid syndrome

L.E. Ciurea, C. Berceanu, E. Brătilă, M.M. Cîrstoiu, R.E. Bohîlțea, S. Berceanu, L.N. Voicu, C. Mehedințu

Rezumat: The progress of biologic and ultrasound assessments in pregnancy has a favorable impact, demonstrated in the case we are presenting, in terms of monitoring the pregnancy reaching the term, in a patient diagnosed with obstetrical antiphospholipid syndrome and septated uterus diagnosed after a previous spontaneous abortion at 6 weeks of gestation, when ultrasonographic evaluation and uterine cavity control have been performed. We pay attention to this case from the point of view of placental abnormalities that can occur if the uterine malformation leads to an anatomical perturbation of the insertion and development of the placenta, but also to the placental abnormalities from the antiphospholipid syndrome in which thrombosis can lead to placental dysfunction. These aspects are supported by laboratory tests that highlight the antiphospholipid antibodies and ultrasound findings obtained from pregnancy monitoring (placental anomalies, fetal growth curve, uterine artery, umbilical artery and middle cerebral artery Doppler flows, amniotic fluid index). From the category of anti-phospholipid antibodies, anti-annexin V antibodies are directly involved in the disruption of placenta as early as 7 weeks of gestation.
Cuvinte cheie: maternal-fetal management, uterine malformations, septated uterus, antiphospholipid syndrome, pregnancy.