REVISTA DE EDUCATIE MEDICALA CONTINUA DEDICATA GINECOLOGILOR,
OBSTETRICENILOR, MOASELOR SI ASISTENTILOR MEDICALI DIN ROMANIA

<- Home <- Arhive <- Anul 3, Nr. 10, December_Supplement_2_ 2015



RevistaGinecologia3(10)53-57(2015)
© VERSA PULS MEDIA, S.R.L.


Non-keratinizing squamous cell carcinoma in a patient with Brenner tumor history - relapse or second cancer?

E. Brătilă, A.M. Manta, C.I. M. Iorga, T.S. Pătrăşcoiu, M.M. Cîrstoiu, C.R. Iorga, C. Berceanu, D.E. Comandaşu, V.D.E. Strâmbu


Rezumat: Mature teratoma represents one of the most frequent ovarian tumors. Yet, its malignization represents a rarity, the most frequent histological type being the squamous-cell carcinoma. Coexistence with Brenner tumor is very rare. Case report. We present the case of a 59-yearold patient, diagnosed 6 years ago with Brenner tumor coexisting with malignant teratoma. The treatment was total hysterectomy and bilateral annexectomy, lymphadenectomy and omentectomyand adjuvant chemotherapy. Six years postoperatively, the patient presents minimum vaginal bleeding and polakyuria, a pelvic tumor being found, invading the urinary bladder. We practiced infralevator anterior pelvectomy with Briker type urinary derivation and adjuvant radiotherapy. Even if the squamous carcinoma represents the most frequent type of malignization of the ovarian malignant teratoma and Brenner tumor, it is not histologically different from other vaginal squamous primary carcinomas. The symptomatology is unspecific, the tumor markers being usually positive. Anatomopathological and immunohistochemical they are similar, p63 positive pleading for epithelial origin. Yet, the free timeframe of the disease in spite of all the paraclinical investigations and periodical oncological consultations negative may plead for a new neoplasia. The correctly directed treatment of an ovarian malign teratoma has led to a good survival of the patient, in spite of the lack of international therapeutic protocols! The accurate treatment of the relapse will determine the prognosis of the the patient, but the main factor is the Brenner tumor’s aggressiveness.
Cuvinte cheie: Brenner tumor, non-keratinizing squamous cell carcinoma, relapse.

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