Prematurity risk in association with human papillomavirus infection
S.D. Popescu, A.M. Bănică, S. Vlădăreanu, A.G. Marin, R. Vladareanu
Rezumat: Prematurity is an important cause of neonatal morbidity
and mortality. Recent studies have shown that human papillomavirus
(HPV) infection also extends to the newborn.
During pregnancy, the risk of obstetric complications,
such as preterm premature rupture of fetal membranes
(PPROM), prematurity, preeclampsia and spontaneous
abortion, increase through inflammatory changes induced
in trophoblast cells and, thus, through histopathologically
identified placental abnormalities. The prevalence of
HPV is increasing among young population, with a peak
around the age of 25 years old. In addition, other infectious
diseases, such as bacterial vaginosis and trichomoniasis,
can also act to cause PPROM by similar mechanisms.
Worldwide, there are three types of inactivated
HPV vaccines (bivalent, quadrivalent and 9-valent),
with the latter (Gardasil-9®) being currently the most
recommended for use in the general population. Even
though HPV vaccination will never reach a 100% coverage,
its implementation in national immunization programs
worldwide is one of the key solutions needed in order to
reduce the impact of prematurity on the newborn. Cuvinte cheie: HPV, prematurity, HPV vaccination, PPROM,
placental disfunction, obstetric adverse outcome.