Sex cord-stromal tumors of the ovary: granulosa-stromal cell tumors. Case report and literature review
L. Mustaţă, G. Peltecu, R. Chirculescu, A.M. Panaitescu, N. Gică, R. Botezatu, R.G. Cigaran, C. Gică, G. Iancu
Rezumat: Background. Sex cord-stromal tumors of the ovary
(SCSTO) are a rare pathology of the ovary, representing
less than 2% from the total primary ovarian cancer cases.
Materials and method. This paper describes a case of
granulosa tumor cell, juvenile type, in a young woman with
secondary amenorrhea and primary infertility. Results.
Granulosa tumor cell, juvenile type, was suspicioned after
clinical and paraclinical tests had been done, and MRI
the ovarian tumor. This case emphasizes the
importance of multidisciplinary team approach, involving
gynecologist, fertility specialist, oncologist, and radiologist.
We have reviewed the available literature in this report.
Although most cases are treated with surgery alone following
oncological safety principles as in epithelial ovarian
cancer approach, it is important to discuss the follow-up
taking into consideration that this patient particularly
wished to procreate, and fertility sparing surgery
was performed. Chemotherapy and radiotherapy were
treatments that were discussed in the
multidisciplinary meeting, but as no adjuvant therapy was
found to be effective, these adjuvant therapies are kept
for recurrence and palliative care for advanced disease.
Close follow-up was arranged for the patient as clinical
and pelvic/abdominal MRI surveillance. Conclusions.
Given the rarity of this disease worldwide, it is important
to raise awareness amongst medical staff and educate
the general population to seek medical attention early. Cuvinte cheie: sex cord-stromal tumors of the ovary,
granulosa tumor cell, juvenile granulosa tumor cells, fertility
sparing surgery, ovarian cancer.