REVISTA DE EDUCATIE MEDICALA CONTINUA DEDICATA GINECOLOGILOR,
OBSTETRICENILOR, MOASELOR SI ASISTENTILOR MEDICALI DIN ROMANIA

<- Home <- Arhive <- Anul 6, Nr. 22, Decembrie 2018



RevistaGinecologia6(22)26-30(2018)
© VERSA PULS MEDIA, S.R.L.


The correlation between patients demographic characteristics and the rate of persistent/recurrent high-grade CIN after conization

C Maier, M Mitran, R Vlădăreanu, E Brătilă


Rezumat: Introduction. Although there has been made great progress in understanding the epidemiology of high-grade cervical intraepithelial lesions (CIN 2/3), the cofactors involved in the dynamics of cervical HPV infection are still a subject of debate. The purpose of this paper was to assess the patients’ demographic characteristics correlated with the risk of lesions’ persistence/recurrence post-cervical excisional therapy for CIN 2/3. Materials and method. We conducted an analytical, observational, prospective cohort study carried out in the “Prof. Dr. Panait Sîrbu” Clinical Hospital of Obstetrics and Gynecology over a 3-year period. We included 290 patients diagnosed with highgrade cervical dysplasia who benefited from conization in our clinic. The demographic variables obtained from the anamnesis were statistically correlated with the rate of persistent/recurrent cervical lesions post-therapy. Results. The mean age for our study group was 44.1 years old; more than half of the patients (73.1%) came from urban environments and were highly educated (54.1%). Regarding personal obstetrical history, most of the patients were multiparous (71.3%), with 14.5% having more than four births and 67.6% having delivered vaginally. The mean age at the first sexual intercourse was 22.13 years old, and more than half of the patients claimed never having used the condom. Nine patients (3.1%) had been diagnosed with immunodeficiency syndromes, out of which six patients were HIV-positive. The multivariate logistic regression analysis showed that age (OR=1.08; p<0.01), smoking status (OR=3.96; p<0.01) and age at first pregnancy (OR=0.87; p<0.01) were independent predictive factors for the risk of persistence/recurrence of CIN lesions. Conclusions. The three factors that were statistically correlated with persistent/recurrent CIN after therapy can be used as a predictive model for clinicians struggling to prevent cervical neoplastic invasive lesions.
Cuvinte cheie: CIN 2/3, persistence/recurrence rate, conization, demographic factors.

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